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Lupus Drug Development

There hasn't been a new drug approved for lupus in more than 40 years. That may change as the pharmaceutical industry and others invest in identifying promising medicines for lupus and examine their safety and effectiveness through clinical trials.

Visit this page frequently to see the latest on these industry developments.

Lupus Drug Development News Archive »

Clinical Trial Results

Every month there are a handful of lupus trial results or drug analyses published in medical journals and posted, in abbreviated form, on the U.S. National Library of Medicine's vast database of biomedical articles (PubMed). Here are some of the stories of interest from recent months.

Incidental discovery of high systemic lupus erythematosus disease activity associated with cytomegalovirus viral activity.
Med Microbiol Immunol. 2007 Sep;196(3):165-170. Epub 2007 Feb 23.

Can mycophenolate mofetil substitute cyclophosphamide treatment of pediatric lupus nephritis?
Pediatr Nephrol. 2007 Aug;22(8):1077-1082. Epub 2007 Mar 17.

What can epidemiology tell us about systemic lupus erythematosus?
Int J Clin Pract. 2007 Jul;61(7):1170-80.

Mycophenolate mofetil in induction and maintenance therapy of severe lupus nephritis: a meta-analysis of randomized controlled trials.
Nephrol Dial Transplant. 2007 Jul;22(7):1933-42. Epub 2007 Apr 3.

Fifty years of anti-ds DNA antibodies: are we approaching journey's end?
Rheumatology (Oxford). 2007 Jul;46(7):1052-6. Epub 2007 May 11

Rituximab in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis and systemic lupus erythematosus: past, present and future.
Kidney Int. 2007 Jul 4; [Epub ahead of print]

Association or lack of association between tetracycline class antibiotics used for acne vulgaris and lupus erythematosus.
Br J Dermatol. 2007 Jun 26; [Epub ahead of print]

The relationship between cancer and medication exposures in systemic lupus erythematosus: a case-cohort study.
Ann Rheum Dis. 2007 Jun 1; [Epub ahead of print]

Antimalarials may influence the risk of malignancy in systemic lupus erythematosus.
Ann Rheum Dis. 2007 Jun;66(6):815-7. Epub 2007 Jan 4.

Mycophenolate sodium for subacute cutaneous lupus erythematosus resistant to standard therapy.
Br J Dermatol. 2007 Jun;156(6):1321-7. Epub 2007 Apr 4.

A multiethnic, multicenter cohort of patients with systemic lupus erythematosus (SLE) as a model for the study of ethnic disparities in SLE.
Arthritis Rheum. 2007 May 15;57(4):576-84.

Association of a common interferon regulatory factor 5 (IRF5) variant with increased risk of systemic lupus erythematosus (SLE).
Ann Hum Genet. 2007 May;71(Pt 3):308-11. Epub 2006 Dec 12.

A prospective study of anti-chromatin and anti-C1q autoantibodies in patients with proliferative lupus nephritis treated with cyclophosphamide pulses or azathioprine/methylprednisolone.
Ann Rheum Dis. 2007 May;66(5):693-6. Epub 2006 Nov 29.

LJP-394 (abetimus sodium) in the treatment of systemic lupus erythematosus.
Expert Opin Pharmacother. 2007 Apr;8(6):873-9. Review.
PMID: 17425481 [PubMed - indexed for MEDLINE]

Histopathologic and clinical outcome of rituximab treatment in patients with cyclophosphamide-resistant proliferative lupus nephritis.
Arthritis Rheum. 2007 Apr;56(4):1263-72.
PMID: 17393458 [PubMed - indexed for MEDLINE]

Clinical effects and safety of rituximab for treatment of refractory pediatric autoimmune diseases.
J Pediatr. 2007 Apr;150(4):376-82.

Reproductive and menopausal factors and risk of systemic lupus erythematosus in women.
Arthritis Rheum. 2007 Apr;56(4):1251-62.

B cell depletion therapy in systemic lupus erythematosus: Long term follow up and predictors of response.
Ann Rheum Dis. 2007 Apr 5; [Epub ahead of print]

[Anti-CD20 therapy for inducing and maintaining remission in refractory systemic lupus erythematosus.]
Z Rheumatol. 2007 Apr 18; [Epub ahead of print] German.

LJP-394 (abetimus sodium) in the treatment of systemic lupus erythematosus.
Expert Opin Pharmacother. 2007 Apr;8(6):873-9. Review.

Human clinical trials in lupus nephritis.
Semin Nephrol. 2007 Jan;27(1):115-27. Review.

Exploring new territory: considering the future.
Lupus. 2007;16(3):221-6. Review.

Exploring new territory: the move towards individualised treatment.
Lupus. 2007;16(3):227-31. Review.

Smoking as a trigger for inflammatory rheumatic diseases.
Curr Opin Rheumatol. 2007 Jan;19(1):49-54.

Three pathogenic determinants in immune nephritis--anti-glomerular antibody specificity, innate triggers and host genetics.
Front Biosci. 2007 Jan 1;12:2207-11.

Complement receptor 2, natural antibodies and innate immunity: Inter-relationships in B cell selection and activation.
Mol Immunol. 2007 Jan;44(1-3):64-72. Epub 2006 Jul 28.

Human lupus autoantibodies against NMDA receptors mediate cognitive impairment.
Proc Natl Acad Sci U S A. 2006 Dec 14.

Severe Lupus Nephritis: Racial Differences in Presentation and Outcome.
J Am Soc Nephrol. 2006 Dec 13.

Systematic review and meta-analysis of randomised trials and cohort studies of mycophenolate mofetil in lupus nephritis.
Arthritis Res Ther. 2006 Dec 12;8(6):R182.

The efficacy of vitamin E against oxidative damage and autoantibody production in systemic lupus erythematosus: a preliminary study.
Clin Rheumatol. 2006 Dec 2.

Modulation of autoimmunity by TLR9 in the chronic graft-vs-host model of systemic lupus erythematosus.
J Immunol. 2006 Nov 15;177(10):7444-50

Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus.
Am J Physiol Regul Integr Comp Physiol. 2006 Nov;291(5):R1527-32.

Ethnicity and mortality from systemic lupus erythematosus in the US.
Ann Rheum Dis. 2006 Nov;65(11):1500-5.

The effect of moderate-dose corticosteroids in preventing severe flares in patients with serologically active, but clinically stable, systemic lupus erythematosus: findings of a prospective, randomized, double-blind, placebo-controlled trial.
Arthritis Rheum. 2006 Nov;54(11):3623-32.

B cell depletion therapy in systemic lupus erythematosus: effect on autoantibody and antimicrobial antibody profiles.
Arthritis Rheum. 2006 Nov;54(11):3612-22.

Predictors of post-partum damage accrual in systemic lupus erythematosus: data from LUMINA, a multiethnic US cohort (XXXVIII).
Rheumatology (Oxford). 2006 Nov;45(11):1380-4.

Toll-like receptors in systemic autoimmune disease.
Nat Rev Immunol. 2006 Nov;6(11):823-35. Review.

Persistent expression of autoantibodies in SLE patients in remission.
J Exp Med. 2006 Oct 2;203(10):2255-61.

Low blood concentration of hydroxychloroquine is a marker for and predictor of disease exacerbations in patients with systemic lupus erythematosus.
Arthritis Rheum. 2006 Oct;54(10):3284-90.

B cell depletion therapy in systemic rheumatic diseases: different strokes for different folks?
Clin Immunol. 2006 Oct;121(1):1-12. Review.

Predictors of Carotid Atherosclerosis in Systemic Lupus Erythematosus.
J Rheumatol. 2006 Oct 1.

Update on the treatment of lupus nephritis.
Kidney Int. 2006 Oct;70(8):1403-12. Review.

Adult stem cells in the treatment of autoimmune diseases.
Rheumatology (Oxford). 2006 Oct;45(10):1187-93. Review.

Systemic lupus erythematosus in a multiethnic cohort: LUMINA XXXV. Predictive factors of high disease activity over time.
Ann Rheum Dis. 2006 Sep;65(9):1168-74.

Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis: Remission, relapse, and re-treatment.
Arthritis Rheum. 2006 Sep;54(9):2970-82.

Clinical trial design in systemic lupus erythematosus.
Curr Opin Rheumatol. 2006 Sep;18(5):476-80.

Epratuzumab (humanised anti-CD22 antibody) in autoimmune diseases.
Expert Opin Biol Ther. 2006 Sep;6(9):943-9. Review.

Neuropsychiatric manifestations in pediatric systemic lupus erythematosus and association with antiphospholipid antibodies.
J Rheumatol. 2006 Sep;33(9):1873-7.

Prognostic factors in lupus nephritis: diagnostic and therapeutic delay increases the risk of terminal renal failure.
J Rheumatol. 2006 Aug;33(8):1563-9.

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Clinical Trial Results Archive »

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